ID   MDA-MB-231GFP
AC   CVCL_E2QK
DR   DSMZ; ACC-981
RX   PubMed=23895436;
RX   PubMed=29569804;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Doubling time: ~24-48 hours (DSMZ=ACC-981).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-981
ST   Amelogenin: X
ST   CSF1PO: 12,13,14
ST   D13S317: 13
ST   D16S539: 12
ST   D18S51: 11
ST   D19S433: 11,14
ST   D21S11: 33.2
ST   D2S1338: 20,21
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 8,9
ST   D8S1179: 13
ST   FGA: 22
ST   Penta D: 14
ST   Penta E: 11
ST   TH01: 7,9.3
ST   TPOX: 8,9
ST   vWA: 15,18
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0062 ! MDA-MB-231
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
//
RX   PubMed=23895436; DOI=10.1089/scd.2013.0249;
RA   Mandel K., Yang Y.-Y., Schambach A., Glage S., Otte A., Hass R.;
RT   "Mesenchymal stem cells directly interact with breast cancer cells and
RT   promote tumor cell growth in vitro and in vivo.";
RL   Stem Cells Dev. 22:3114-3127(2013).
//
RX   PubMed=29569804; DOI=10.1002/stem.2819;
RA   Melzer C., von der Ohe J., Hass R.;
RT   "In vitro fusion of normal and neoplastic breast epithelial cells with
RT   human mesenchymal stroma/stem cells partially involves tumor necrosis
RT   factor receptor signaling.";
RL   Stem Cells 36:977-989(2018).
//