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Cellosaurus HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T (CVCL_E2Q6)

[Text version]
Cell line name HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T
Synonyms hJAK2_p.V617F_c.1849G>T MEG-01
Accession CVCL_E2Q6
Resource Identification Initiative To cite this cell line use: HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T (RRID:CVCL_E2Q6)
Comments Population: Japanese.
Doubling time: 24-48 hours (Hysigen=CGKO-M2166).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; 18318; ASXL1; Simple; p.Gly646Trpfs*12 (c.1934dupG); ClinVar=VCV000426927; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6192; JAK2; Simple_edited; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous; Note=By CRISPR/Cas9 (Hysigen=CGMU-M2166).
  • Mutation; HGNC; 11998; TP53; Simple; p.His233del (c.697_699delCAC); Zygosity=Heterozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0425 (MEG-01)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGMU-M2166
Entry history
Entry creation10-Sep-2024
Last entry update10-Sep-2024
Version number1