ID   HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T
AC   CVCL_E2Q6
SY   hJAK2_p.V617F_c.1849G>T MEG-01
DR   Hysigen; CGMU-M2166
CC   Population: Japanese.
CC   Doubling time: 24-48 hours (Hysigen=CGKO-M2166).
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 18318; ASXL1; Simple; p.Gly646Trpfs*12 (c.1934dupG); ClinVar=VCV000426927; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6192; JAK2; Simple_edited; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous; Note=By CRISPR/Cas9 (Hysigen=CGMU-M2166).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His233del (c.697_699delCAC); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0425 ! MEG-01
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 10-09-24; Last updated: 10-09-24; Version: 1
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