Cell line name |
Ubigene Jurkat, Clone E6-1 CARD8 KO |
Synonyms |
CARD8 Knockout cell line (Jurkat, Clone E6-1) |
Accession |
CVCL_E0WG |
Resource Identification Initiative |
To cite this cell line use: Ubigene Jurkat, Clone E6-1 CARD8 KO (RRID:CVCL_E0WG) |
Comments |
Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; 17057; CARD8. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0367 (Jurkat E6.1) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Cross-references |
Cell line collections (Providers) |
Ubigene; YKO-H771
|
Entry history |
Entry creation | 10-Sep-2024 |
Last entry update | 10-Sep-2024 |
Version number | 1 |
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