• Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  

PubMed=1301400; DOI=10.1016/0303-7207(92)90104-E
Jiang S.-Y., Wolf D.M., Yingling J.M., Chang C.-S., Jordan V.C.
An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.
Mol. Cell. Endocrinol. 90:77-86(1992)

PubMed=9242427
Levenson A.S., Jordan V.C.
MCF-7: the first hormone-responsive breast cancer cell line.
Cancer Res. 57:3071-3078(1997)

PubMed=15862958; DOI=10.1016/j.jsbmb.2004.12.032
Lewis-Lambi J.S., Osipo C., Meeke K., Jordan V.C.
Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal.
J. Steroid Biochem. Mol. Biol. 94:131-141(2005)

PubMed=16333030; DOI=10.1093/jnci/dji400
Lewis-Wambi J.S., Meeke K., Osipo C., Ross E.A., Kidawi N., Li T.-Y., Bell E., Chandel N.S., Jordan V.C.
Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.
J. Natl. Cancer Inst. 97:1746-1759(2005)

PubMed=24604139; DOI=10.3892/ijo.2014.2329; PMCID=PMC4144033
Sweeney E.E., Fan P., Jordan V.C.
Mechanisms underlying differential response to estrogen-induced apoptosis in long-term estrogen-deprived breast cancer cells.
Int. J. Oncol. 44:1529-1538(2014)

PubMed=32453591; DOI=10.1021/acs.jmedchem.0c00456; PMCID=PMC8258866
Li Y.-F., Zhao J., Gutgesell L.M., Shen Z.-N., Ratia K., Dye K., Dubrovskyi O., Zhao H.-P., Huang F., Tonetti D.A., Thatcher G.R.J., Xiong R.
Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and palbociclib.
J. Med. Chem. 63:7186-7210(2020)