ID   MCF-7.5C
AC   CVCL_DC70
SY   MCF7:5C; MCF-7 clone 5C; 5C
DR   cancercelllines; CVCL_DC70
DR   Wikidata; Q54904329
RX   PubMed=9242427;
RX   PubMed=1301400;
RX   PubMed=15862958;
RX   PubMed=16333030;
RX   PubMed=24604139;
RX   PubMed=32453591;
CC   Population: Caucasian.
CC   Characteristics: Undergoes rapid and complete apoptosis in the presence of physiologic concentrations of 17-alpha-estradiol.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 02-05-24; Version: 14
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RX   PubMed=9242427;
RA   Levenson A.S., Jordan V.C.;
RT   "MCF-7: the first hormone-responsive breast cancer cell line.";
RL   Cancer Res. 57:3071-3078(1997).
//
RX   PubMed=1301400; DOI=10.1016/0303-7207(92)90104-E;
RA   Jiang S.-Y., Wolf D.M., Yingling J.M., Chang C.-S., Jordan V.C.;
RT   "An estrogen receptor positive MCF-7 clone that is resistant to
RT   antiestrogens and estradiol.";
RL   Mol. Cell. Endocrinol. 90:77-86(1992).
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RX   PubMed=15862958; DOI=10.1016/j.jsbmb.2004.12.032;
RA   Lewis-Lambi J.S., Osipo C., Meeke K., Jordan V.C.;
RT   "Estrogen-induced apoptosis in a breast cancer model resistant to
RT   long-term estrogen withdrawal.";
RL   J. Steroid Biochem. Mol. Biol. 94:131-141(2005).
//
RX   PubMed=16333030; DOI=10.1093/jnci/dji400;
RA   Lewis-Wambi J.S., Meeke K., Osipo C., Ross E.A., Kidawi N., Li T.-Y.,
RA   Bell E., Chandel N.S., Jordan V.C.;
RT   "Intrinsic mechanism of estradiol-induced apoptosis in breast cancer
RT   cells resistant to estrogen deprivation.";
RL   J. Natl. Cancer Inst. 97:1746-1759(2005).
//
RX   PubMed=24604139; DOI=10.3892/ijo.2014.2329; PMCID=PMC4144033;
RA   Sweeney E.E., Fan P., Jordan V.C.;
RT   "Mechanisms underlying differential response to estrogen-induced
RT   apoptosis in long-term estrogen-deprived breast cancer cells.";
RL   Int. J. Oncol. 44:1529-1538(2014).
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RX   PubMed=32453591; DOI=10.1021/acs.jmedchem.0c00456; PMCID=PMC8258866;
RA   Li Y.-F., Zhao J., Gutgesell L.M., Shen Z.-N., Ratia K., Dye K.,
RA   Dubrovskyi O., Zhao H.-P., Huang F., Tonetti D.A., Thatcher G.R.J.,
RA   Xiong R.;
RT   "Novel pyrrolopyridone bromodomain and extra-terminal motif (BET)
RT   inhibitors effective in endocrine-resistant ER+ breast cancer with
RT   acquired resistance to fulvestrant and palbociclib.";
RL   J. Med. Chem. 63:7186-7210(2020).
//