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Cellosaurus NZM042 (CVCL_D833)

[Text version]
Cell line name NZM042
Synonyms NZM42
Accession CVCL_D833
Resource Identification Initiative To cite this cell line use: NZM042 (RRID:CVCL_D833)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 70-80 hours (CBA=CBA-1391).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Not specified.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=32567790; CBA=CBA-1391).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
HLA typing Source: PubMed=32567790
Class I
HLA-AA*03:01,11:01
HLA-BB*07:02,45:01
HLA-CC*06:02,07:02
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S423 ! NZM048
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1391; PubMed=32567790

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,20
D3S135816,17
D5S81812,13
D7S8208,10
D8S117914
D13S3178,11
D16S5399,11
D18S5114,16
D19S43315
D21S1129,32.2
FGA19,20
Penta D13,15
Penta E15,18
TH019,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=20041153; DOI=10.1371/journal.pone.0008461; PMCID=PMC2794539
Jeffs A.R., Glover A.C., Slobbe L.J., Wang L., He S.-J., Hazlett J.A., Awasthi A., Woolley A.G., Marshall E.S., Joseph W.R., Print C.G., Baguley B.C., Eccles M.R.
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:E8461-E8461(2009)

PubMed=22475322; DOI=10.1186/1471-2407-12-141; PMCID=PMC3352269
Kim J.E., Stones C.J., Joseph W.R., Leung E.Y., Finlay G.J., Shelling A.N., Phillips W.A., Shepherd P.R., Baguley B.C.
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC Cancer 12:141.1-141.10(2012)

PubMed=32567790; DOI=10.1111/pcmr.12908; PMCID=PMC7818249
Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J., Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S., Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1391
Cell line databases/resources cancercelllines; CVCL_D833
DepMap; ACH-001986
Biological sample resources BioSample; SAMN07624447
BioSample; SAMN14558339
Encyclopedic resources Wikidata; Q54931576
Polymorphism and mutation databases Cosmic; 1660298
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number20