Cellosaurus logo
expasy logo

Cellosaurus HEK293T_HTT null (CVCL_D7EP)

[Text version]
Cell line name HEK293T_HTT null
Accession CVCL_D7EP
Resource Identification Initiative To cite this cell line use: HEK293T_HTT null (RRID:CVCL_D7EP)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4851; HTT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA).
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0063 (HEK293T)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=33432339; DOI=10.1093/hmg/ddaa283; PMCID=PMC8248964
Jung R., Lee Y., Barker D., Correia K., Shin B., Loupe J., Collins R.L., Lucente D., Ruliera J., Gillis T., Mysore J.S., Rodan L., Picker J., Lee J.-M., Howland D.S., Lee R., Kwak S., MacDonald M.E., Gusella J.F., Seong I.S.
Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs.
Hum. Mol. Genet. 30:135-148(2021)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2