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Cellosaurus N2aSW (CVCL_D650)

[Text version]
Cell line name N2aSW
Synonyms N2aSw; N2Asw-APP; Swe.24; N2a/APPsw; N2a-APPsw; N2a-APPswe; N2A-APPswe; N2A APPsw; N2aAPPsw
Accession CVCL_D650
Resource Identification Initiative To cite this cell line use: N2aSW (RRID:CVCL_D650)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:620; APP (Note=With p.Lys670Asn and p.Met671Leu).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
Cell type: Neural crest derived neuroblast; CL=CL_0002676.
Disease Mouse neuroblastoma (NCIt: C21993)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: A/J.
Hierarchy Parent: CVCL_0470 (Neuro-2a)
Sex of cell Male
Category Cancer cell line
Publications

PubMed=8621605; DOI=10.1074/jbc.271.16.9390
Thinakaran G., Teplow D.B., Siman R., Greenberg B., Sisodia S.S.
Metabolism of the 'Swedish' amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the 'beta-secretase' site occurs in the Golgi apparatus.
J. Biol. Chem. 271:9390-9397(1996)

Cross-references
Anatomy/cell type resources BTO; BTO_0002663
Encyclopedic resources Wikidata; Q54907340
Proteomic databases PRIDE; PXD032733
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number15