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Cellosaurus DU145/RC1 (CVCL_D639)

[Text version]
Cell line name DU145/RC1
Synonyms DU-145/RC1; DU-145/RC; RC1
Accession CVCL_D639
Resource Identification Initiative To cite this cell line use: DU145/RC1 (RRID:CVCL_D639)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11986; TOP1; Simple; p.Arg364His (c.1091G>A); Zygosity=Homozygous (PubMed=11280753).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line

PubMed=8993507; DOI=10.1111/j.1749-6632.1996.tb26383.x
Chatterjee D., Wyche J.H., Pantazis P.
Induction of apoptosis in malignant and camptothecin-resistant human cells.
Ann. N. Y. Acad. Sci. 803:143-156(1996)

Urasaki Y., Laco G.S., Pourquier P., Takebayashi Y., Kohlhagen G., Gioffre C., Zhang H.-L., Chatterjee D., Pantazis P., Pommier Y.
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer Res. 61:1964-1969(2001)

Cell line databases/resources cancercelllines; CVCL_D639
Encyclopedic resources Wikidata; Q54831576
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number21