| Cell line name |
DU145/RC1 |
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| Synonyms |
DU-145/RC1; DU-145/RC; RC1 |
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| Accession |
CVCL_D639 |
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| Resource Identification Initiative |
To cite this cell line use: DU145/RC1 (RRID:CVCL_D639) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
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| Sequence variations |
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11986; TOP1; Simple; p.Arg364His (c.1091G>A); Zygosity=Homozygous (PubMed=11280753).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0105 (DU145) |
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| Sex of cell |
Male |
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| Age at sampling |
69Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8993507; DOI=10.1111/j.1749-6632.1996.tb26383.x
Chatterjee D., Wyche J.H., Pantazis P.
Induction of apoptosis in malignant and camptothecin-resistant human cells.
Ann. N. Y. Acad. Sci. 803:143-156(1996) PubMed=11280753
Urasaki Y., Laco G.S., Pourquier P., Takebayashi Y., Kohlhagen G., Gioffre C., Zhang H.-L., Chatterjee D., Pantazis P., Pommier Y.
Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.
Cancer Res. 61:1964-1969(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_D639
|
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| Encyclopedic resources |
Wikidata; Q54831576
|
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 22 |
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