ID   DU145/RC1
AC   CVCL_D639
SY   DU-145/RC1; DU-145/RC; RC1
DR   cancercelllines; CVCL_D639
DR   Wikidata; Q54831576
RX   PubMed=8993507;
RX   PubMed=11280753;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:90225; Rubitecan (Orathecin; 9-nitrocamptothecin; 9NC).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11986; TOP1; Simple; p.Arg364His (c.1091G>A); Zygosity=Homozygous (PubMed=11280753).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0105 ! DU145
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=8993507; DOI=10.1111/j.1749-6632.1996.tb26383.x;
RA   Chatterjee D., Wyche J.H., Pantazis P.;
RT   "Induction of apoptosis in malignant and camptothecin-resistant human
RT   cells.";
RL   Ann. N. Y. Acad. Sci. 803:143-156(1996).
//
RX   PubMed=11280753;
RA   Urasaki Y., Laco G.S., Pourquier P., Takebayashi Y., Kohlhagen G.,
RA   Gioffre C., Zhang H.-L., Chatterjee D., Pantazis P., Pommier Y.;
RT   "Characterization of a novel topoisomerase I mutation from a
RT   camptothecin-resistant human prostate cancer cell line.";
RL   Cancer Res. 61:1964-1969(2001).
//