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Cellosaurus HepG2-DP (CVCL_D5I8)

[Text version]
Cell line name HepG2-DP
Synonyms HepG2-DP clone No.4; DP-4; DNMT1/PKR double knockdowned HepG2
Accession CVCL_D5I8
Resource Identification Initiative To cite this cell line use: HepG2-DP (RRID:CVCL_D5I8)
Comments Population: Caucasian.
Characteristics: Has improved hepatic function (PubMed=36476676).
Knockout cell: Method=shRNA knockdown; HGNC; 2976; DNMT1.
Knockout cell: Method=shRNA knockdown; HGNC; 9437; EIF2AK2.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1978

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811,12
D7S82010
D13S3179,13
D16S53912,13
TH019
TPOX8,9
vWA17

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Publications

PubMed=36476676; DOI=10.1038/s41598-022-25777-z; PMCID=PMC9729623
Tanaka-Yachi R., Aizawa K., Shimizu K., Akutsu H., Nakamura K.
DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability.
Sci. Rep. 12:21173-21173(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1978
Encyclopedic resources Wikidata; Q127381751
Entry history
Entry creation02-May-2024
Last entry update10-Sep-2024
Version number2