ID   HepG2-DP
AC   CVCL_D5I8
SY   HepG2-DP clone No.4; DP-4; DNMT1/PKR double knockdowned HepG2
DR   JCRB; JCRB1978
DR   Wikidata; Q127381751
RX   PubMed=36476676;
CC   Population: Caucasian.
CC   Characteristics: Has improved hepatic function (PubMed=36476676).
CC   Knockout cell: Method=shRNA knockdown; HGNC; 2976; DNMT1.
CC   Knockout cell: Method=shRNA knockdown; HGNC; 9437; EIF2AK2.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): JCRB=JCRB1978
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 9,13
ST   D16S539: 12,13
ST   D5S818: 11,12
ST   D7S820: 10
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 02-05-24; Last updated: 10-09-24; Version: 2
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RX   PubMed=36476676; DOI=10.1038/s41598-022-25777-z; PMCID=PMC9729623;
RA   Tanaka-Yachi R., Aizawa K., Shimizu K., Akutsu H., Nakamura K.;
RT   "DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic
RT   function and differentiation ability.";
RL   Sci. Rep. 12:21173-21173(2022).
//