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Cellosaurus 85As2 (CVCL_D5HV)

[Text version]
Cell line name 85As2
Accession CVCL_D5HV
Resource Identification Initiative To cite this cell line use: 85As2 (RRID:CVCL_D5HV)
Comments Population: Japanese.
Characteristics: Metastatic and cachexia-inducing (PubMed=23659450).
Characteristics: The parent cell line was orthotopically grafted into mice, and peritoneal cavity cells were collected from specimens exhibiting peritoneal metastasis. These cells were then cultured and xenografted. This process was carried out 11 times (PubMed=23659450).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
Disease Gastric adenocarcinoma (NCIt: C4004)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D5HU (MKN45cl85)
Children:
CVCL_D5HW (85As2mLuc)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1950

Markers:
AmelogeninX
CSF1PO12
D5S81810,11
D7S82010,11
D13S3178,11
D16S53910
TH017
TPOX8
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=23659450; DOI=10.1080/01635581.2013.776089
Yanagihara K., Takigahira M., Mihara K., Kubo T., Morimoto C., Morita Y., Terawaki K., Uezono Y., Seyama T.
Inhibitory effects of isoflavones on tumor growth and cachexia in newly established cachectic mouse models carrying human stomach cancers.
Nutr. Cancer 65:578-589(2013)

PubMed=30410674; DOI=10.18632/oncotarget.26190; PMCID=PMC6205166
Terawaki K., Kashiwase Y., Uzu M., Nonaka M., Sawada Y., Miyano K., Higami Y., Yanagihara K., Yamamoto M., Uezono Y.
Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats.
Oncotarget 9:34748-34764(2018)

Cross-references
Cell line collections (Providers) JCRB; JCRB1950
Encyclopedic resources Wikidata; Q127378795
Gene expression databases GEO; GSM3097054
GEO; GSM3097055
GEO; GSM3097056
Entry history
Entry creation02-May-2024
Last entry update19-Dec-2024
Version number3