ID   85As2
AC   CVCL_D5HV
DR   GEO; GSM3097054
DR   GEO; GSM3097055
DR   GEO; GSM3097056
DR   JCRB; JCRB1950
DR   Wikidata; Q127378795
RX   PubMed=23659450;
RX   PubMed=30410674;
CC   Population: Japanese.
CC   Characteristics: Metastatic and cachexia-inducing (PubMed=23659450).
CC   Characteristics: The parent cell line was orthotopically grafted into mice, and peritoneal cavity cells were collected from specimens exhibiting peritoneal metastasis. These cells were then cultured and xenografted. This process was carried out 11 times (PubMed=23659450).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
ST   Source(s): JCRB=JCRB1950
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 10
ST   D5S818: 10,11
ST   D7S820: 10,11
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 19
DI   NCIt; C4004; Gastric adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D5HU ! MKN45cl85
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 02-05-24; Last updated: 10-09-24; Version: 2
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RX   PubMed=23659450; DOI=10.1080/01635581.2013.776089;
RA   Yanagihara K., Takigahira M., Mihara K., Kubo T., Morimoto C.,
RA   Morita Y., Terawaki K., Uezono Y., Seyama T.;
RT   "Inhibitory effects of isoflavones on tumor growth and cachexia in
RT   newly established cachectic mouse models carrying human stomach
RT   cancers.";
RL   Nutr. Cancer 65:578-589(2013).
//
RX   PubMed=30410674; DOI=10.18632/oncotarget.26190; PMCID=PMC6205166;
RA   Terawaki K., Kashiwase Y., Uzu M., Nonaka M., Sawada Y., Miyano K.,
RA   Higami Y., Yanagihara K., Yamamoto M., Uezono Y.;
RT   "Leukemia inhibitory factor via the Toll-like receptor 5 signaling
RT   pathway involves aggravation of cachexia induced by human gastric
RT   cancer-derived 85As2 cells in rats.";
RL   Oncotarget 9:34748-34764(2018).
//