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Cellosaurus KH-450 (CVCL_D5AX)

[Text version]
Cell line name KH-450
Synonyms KH450
Accession CVCL_D5AX
Resource Identification Initiative To cite this cell line use: KH-450 (RRID:CVCL_D5AX)
Comments Population: Caucasian.
Doubling time: 65 hours (CelloPub=CLPUB00761).
Selected for resistance to: ChEBI; CHEBI:44423; Hydroxyurea.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D5D2 (KH-375)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=3622008; DOI=10.1159/000132438
Tonin P.N., Stallings R.L., Carman M.D., Bertino J.R., Wright J.A., Srinivasan P.R., Lewis W.H.
Chromosomal assignment of amplified genes in hydroxyurea-resistant hamster cells.
Cytogenet. Cell Genet. 45:102-108(1987)

CLPUB00761
Carman M.D.
Altered and increased ribonucleotide reductase activity as a mechanism of resistance to hydroxyurea in a human myelogenous leukemia cell line.
Thesis PhD (1988); Yale University; New Haven; USA

Cross-references
Encyclopedic resources Wikidata; Q127382425
Entry history
Entry creation02-May-2024
Last entry update10-Sep-2024
Version number2