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Cellosaurus HEK293-NOD2 L1007fsinsC (CVCL_D4ZM)

[Text version]
Cell line name HEK293-NOD2 L1007fsinsC
Synonyms FLP-IN HEK 293-NOD2-L1007fsinsC; HEK293-NOD2(SNP13)
Accession CVCL_D4ZM
Resource Identification Initiative To cite this cell line use: HEK293-NOD2 L1007fsinsC (RRID:CVCL_D4ZM)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; 5331; NOD2 (Note=With p.Leu1007Profs*2).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U427 (Flp-In-T-REx-293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=16257953; DOI=10.1074/jbc.M505986200
Weichart D., Gobom J., Klopfleisch S., Hasler R., Gustavsson N., Billmann-Born S., Lehrach H., Seegert D., Schreiber S., Rosenstiel P.
Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.
J. Biol. Chem. 281:2380-2389(2006)

PubMed=21335489; DOI=10.4049/jimmunol.1000085
Billmann-Born S., Till A., Arlt A., Lipinski S., Sina C., Latiano A., Annese V., Hasler R., Kerick M., Manke T., Seegert D., Hanidu A., Schafer H., van Heel D., Li J., Schreiber S., Rosenstiel P.
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
J. Immunol. 186:4027-4038(2011)

Cross-references
Encyclopedic resources Wikidata; Q127381646
Gene expression databases GEO; GSM560858
GEO; GSM560859
GEO; GSM560860
GEO; GSM560867
GEO; GSM560868
GEO; GSM560869
GEO; GSM560876
GEO; GSM560877
GEO; GSM560878
Entry history
Entry creation02-May-2024
Last entry update10-Sep-2024
Version number2