ID   HEK293-NOD2 L1007fsinsC
AC   CVCL_D4ZM
SY   FLP-IN HEK 293-NOD2-L1007fsinsC; HEK293-NOD2(SNP13)
DR   GEO; GSM560858
DR   GEO; GSM560859
DR   GEO; GSM560860
DR   GEO; GSM560867
DR   GEO; GSM560868
DR   GEO; GSM560869
DR   GEO; GSM560876
DR   GEO; GSM560877
DR   GEO; GSM560878
DR   Wikidata; Q127381646
RX   PubMed=16257953;
RX   PubMed=21335489;
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 5331; NOD2 (Note=With p.Leu1007Profs*2).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_U427 ! Flp-In-T-REx-293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 02-05-24; Last updated: 10-09-24; Version: 2
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RX   PubMed=16257953; DOI=10.1074/jbc.M505986200;
RA   Weichart D., Gobom J., Klopfleisch S., Hasler R., Gustavsson N.,
RA   Billmann-Born S., Lehrach H., Seegert D., Schreiber S., Rosenstiel P.;
RT   "Analysis of NOD2-mediated proteome response to muramyl dipeptide in
RT   HEK293 cells.";
RL   J. Biol. Chem. 281:2380-2389(2006).
//
RX   PubMed=21335489; DOI=10.4049/jimmunol.1000085;
RA   Billmann-Born S., Till A., Arlt A., Lipinski S., Sina C., Latiano A.,
RA   Annese V., Hasler R., Kerick M., Manke T., Seegert D., Hanidu A.,
RA   Schafer H., van Heel D., Li J., Schreiber S., Rosenstiel P.;
RT   "Genome-wide expression profiling identifies an impairment of negative
RT   feedback signals in the Crohn's disease-associated NOD2 variant
RT   L1007fsinsC.";
RL   J. Immunol. 186:4027-4038(2011).
//