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Cellosaurus HEK293-NOD2 (CVCL_D4ZL)

[Text version]
Cell line name HEK293-NOD2
Synonyms FLP-IN HEK 293-NOD2wt
Accession CVCL_D4ZL
Resource Identification Initiative To cite this cell line use: HEK293-NOD2 (RRID:CVCL_D4ZL)
Comments Genetic integration: Method=Transfection/transduction; Gene=HGNC; 5331; NOD2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 28285; Adenovirus 5.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_U427 (Flp-In-T-REx-293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=16257953; DOI=10.1074/jbc.M505986200
Weichart D., Gobom J., Klopfleisch S., Hasler R., Gustavsson N., Billmann-Born S., Lehrach H., Seegert D., Schreiber S., Rosenstiel P.
Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.
J. Biol. Chem. 281:2380-2389(2006)

PubMed=21335489; DOI=10.4049/jimmunol.1000085
Billmann-Born S., Till A., Arlt A., Lipinski S., Sina C., Latiano A., Annese V., Hasler R., Kerick M., Manke T., Seegert D., Hanidu A., Schafer H., van Heel D., Li J., Schreiber S., Rosenstiel P.
Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.
J. Immunol. 186:4027-4038(2011)

Cross-references
Encyclopedic resources Wikidata; Q127381645
Gene expression databases GEO; GSM560855
GEO; GSM560856
GEO; GSM560857
GEO; GSM560864
GEO; GSM560865
GEO; GSM560866
GEO; GSM560873
GEO; GSM560874
GEO; GSM560875
Entry history
Entry creation02-May-2024
Last entry update10-Sep-2024
Version number2