• Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Arg776Met (c.2327G>T); Zygosity=Heterozygous (PubMed=35124168).
  
• Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168).
  

PubMed=18599181; DOI=10.1016/j.exphem.2008.04.011
Dida F., Li Y.-F., Iwao A., Deguchi T., Azuma E., Komada Y.
Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells.
Exp. Hematol. 36:1343-1353(2008)

PubMed=32144432; DOI=10.1007/s00280-020-04045-9
Goto H., Yoshino Y., Ito M., Nagai J.-i., Kumamoto T., Inukai T., Sakurai Y., Miyagawa N., Keino D., Yokosuka T., Iwasaki F., Hamanoue S., Shiomi M., Goto S.
Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 85:773-783(2020)

PubMed=32862292; DOI=10.1007/s12185-020-02981-z
Kihira K., Chelakkot V.S., Kainuma H., Okumura Y., Tsuboya N., Okamura S., Kurihara K., Iwamoto S., Komada Y., Hori H.
Close interaction with bone marrow mesenchymal stromal cells induces the development of cancer stem cell-like immunophenotype in B cell precursor acute lymphoblastic leukemia cells.
Int. J. Hematol. 112:795-806(2020)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)