ID   MB-IT
AC   CVCL_D3ZA
SY   MBIT; Mie BCP-ALL-IT
DR   Wikidata; Q127382738
RX   PubMed=18599181;
RX   PubMed=32144432;
RX   PubMed=32862292;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Arg776Met (c.2327G>T); Zygosity=Heterozygous (PubMed=35124168).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168).
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Children
CA   Cancer cell line
DT   Created: 30-01-24; Last updated: 19-12-24; Version: 3
//
RX   PubMed=18599181; DOI=10.1016/j.exphem.2008.04.011;
RA   Dida F., Li Y.-F., Iwao A., Deguchi T., Azuma E., Komada Y.;
RT   "Resistance to TRAIL-induced apoptosis caused by constitutional
RT   phosphorylation of Akt and PTEN in acute lymphoblastic leukemia
RT   cells.";
RL   Exp. Hematol. 36:1343-1353(2008).
//
RX   PubMed=32144432; DOI=10.1007/s00280-020-04045-9;
RA   Goto H., Yoshino Y., Ito M., Nagai J.-i., Kumamoto T., Inukai T.,
RA   Sakurai Y., Miyagawa N., Keino D., Yokosuka T., Iwasaki F.,
RA   Hamanoue S., Shiomi M., Goto S.;
RT   "Aurora B kinase as a therapeutic target in acute lymphoblastic
RT   leukemia.";
RL   Cancer Chemother. Pharmacol. 85:773-783(2020).
//
RX   PubMed=32862292; DOI=10.1007/s12185-020-02981-z;
RA   Kihira K., Chelakkot V.S., Kainuma H., Okumura Y., Tsuboya N.,
RA   Okamura S., Kurihara K., Iwamoto S., Komada Y., Hori H.;
RT   "Close interaction with bone marrow mesenchymal stromal cells induces
RT   the development of cancer stem cell-like immunophenotype in B cell
RT   precursor acute lymphoblastic leukemia cells.";
RL   Int. J. Hematol. 112:795-806(2020).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//