Cellosaurus Neuro2a-tNhtt-EGFP-60Q (CVCL_D3YS)
| Cell line name | Neuro2a-tNhtt-EGFP-60Q |
|---|---|
| Accession | CVCL_D3YS |
| Resource Identification Initiative | To cite this cell line use: Neuro2a-tNhtt-EGFP-60Q (RRID:CVCL_D3YS) |
| Comments | Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR (from parent cell line). Characteristics: Transfected with a ecdysone inducible pIND-HDexon1-EGFP construct containing the first exon of HTT with a 60 Gln repeat followed by EGFP (PubMed=10574348). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4851; HTT (Note=1st exon with 60-Q run). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:10477; RXRA. Genetic integration: Method=Transfection/transduction; Gene=FlyBase_Gene; FBgn0000546; EcR (Note=With p.Met1_Val221del, as 2nd part of VgECR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Thr412del, as 1st part of VgECR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010. Cell type: Neural crest derived neuroblast; CL=CL_0002676. |
| Disease | Mouse neuroblastoma (NCIt: C21993) |
| Species of origin | Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: A/J. |
| Hierarchy | Parent: CVCL_D3XR (Neuro2a-RXR) |
| Sex of cell | Male |
| Category | Cancer cell line |
| Publications | PubMed=10574348; DOI=10.1097/00001756-199908200-00001 |
| Cross-references | |
| Cell line collections (Providers) | RCB; RCB5513 |
| Encyclopedic resources | Wikidata; Q127382950 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 19-Dec-2024 |
| Version number | 3 |