Cellosaurus RT4 NF2.K413E #8 (CVCL_D3Y3)
| Cell line name | RT4 NF2.K413E #8 |
|---|---|
| Accession | CVCL_D3Y3 |
| Resource Identification Initiative | To cite this cell line use: RT4 NF2.K413E #8 (RRID:CVCL_D3Y3) |
| Comments | Characteristics: Expression of NF2 is doxycycline-inducible as the parent cell line was transfected with reverse tetracycline-controlled transactivator (rtTA), a fusion between a mutated version of E.coli TetR and the activating domain of HSV-1 VP16 (PubMed=11448944). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7773; NF2 (Note=With p.Lys413Glu). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (Note=With p.Met1_Arg360del). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU). Derived from site: In situ; Peripheral nervous system, sciatic nerve; UBERON=UBERON_0001322. Cell type: Schwann cell; CL=CL_0002573. |
| Disease | Rat malignant schwannoma (NCIt: C60465) |
| Species of origin | Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: BDIX; RS=RS:0000091. |
| Hierarchy | Parent: CVCL_4006 (RT4-D6P2T) |
| Category | Cancer cell line |
| Publications | PubMed=11448944; DOI=10.1093/hmg/10.14.1519 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q127384085 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 19-Dec-2024 |
| Version number | 3 |