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Cellosaurus U-2 OS/IDH1-R132G (CVCL_D3DD)

[Text version]
Cell line name U-2 OS/IDH1-R132G
Accession CVCL_D3DD
Resource Identification Initiative To cite this cell line use: U-2 OS/IDH1-R132G (RRID:CVCL_D3DD)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5382; IDH1 (Note=With p.Arg132Gly).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=25753205; DOI=10.1016/j.bbrc.2015.02.162
Liu X., Ogasawara S., Kaneko M.K., Oki H., Hozumi Y., Goto K., Takagi M., Kato Y.
A novel monoclonal antibody SMab-2 recognizes endogenous IDH2-R172S of chondrosarcoma.
Biochem. Biophys. Res. Commun. 459:636-642(2015)

Cross-references
Encyclopedic resources Wikidata; Q127384419
Entry history
Entry creation30-Jan-2024
Last entry update19-Dec-2024
Version number3