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Cellosaurus CHO-CHRC5 (CVCL_D266)

[Text version]
Cell line name CHO-CHRC5
Synonyms CHO/CHRC5; CHO CHRC5; CHRC/5; CHRC5; CHrC5; CHORC5
Accession CVCL_D266
Resource Identification Initiative To cite this cell line use: CHO-CHRC5 (RRID:CVCL_D266)
Comments Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D264 (CHO-AUXB1)
Children:
CVCL_4703 (CHO-CHRB30)CVCL_C7GL (CHORC5 DeltaP-gp A1)CVCL_C7GM (CHORC5 DeltaP-gp A2)
CVCL_C7GN (CHORC5 DeltaP-gp A3)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=4855907; DOI=10.1002/jcp.1040830114
Ling V., Thompson L.H.
Reduced permeability in CHO cells as a mechanism of resistance to colchicine.
J. Cell. Physiol. 83:103-116(1974)

PubMed=2412130; DOI=10.1038/316820a0
Kartner N., Evernden-Porelle D., Bradley G., Ling V.
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.
Nature 316:820-823(1985)

PubMed=3567908
Jongsma A.P.M., Spengler B.A., van der Bliek A.M., Borst P., Biedler J.L.
Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.
Cancer Res. 47:2875-2878(1987)

PubMed=2458323; DOI=10.1002/ijc.2910420314
Scheper R.J., Bulte J.W.M., Brakkee J.G.P., Quak J.J., van der Schoot C.E., Balm A.J.M., Meijer C.J.L.M., Broxterman H.J., Kuiper C.M., Lankelma J., Pinedo H.M.
Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance.
Int. J. Cancer 42:389-394(1988)

PubMed=3365701
Biedler J.L., Chang T.-D., Scotto K.W., Melera P.W., Spengler B.A.
Chromosomal organization of amplified genes in multidrug-resistant Chinese hamster cells.
Cancer Res. 48:3179-3187(1988)

PubMed=2158805; DOI=10.1038/bjc.1990.127; PMCID=PMC1971365
Boscoboinik D.O., Gupta R.S., Epand R.M.
Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells.
Br. J. Cancer 61:568-572(1990)

PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148
Limniatis G., Georges E.
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO(R)C5 multidrug resistant cells.
Biochem. Biophys. Res. Commun. 608:23-29(2022)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307930
ChEMBL-Targets; CHEMBL614457
PubChem_Cell_line; CVCL_D266
Encyclopedic resources Wikidata; Q54812654
Entry history
Entry creation22-Oct-2012
Last entry update30-Jan-2024
Version number14