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Cellosaurus CHORC5 DeltaP-gp A2 (CVCL_C7GM)

[Text version]
Cell line name CHORC5 DeltaP-gp A2
Accession CVCL_C7GM
Resource Identification Initiative To cite this cell line use: CHORC5 DeltaP-gp A2 (RRID:CVCL_C7GM)
Comments Characteristics: Shows complete reversal of the resistance to both colchicine and doxorubicin which exist in the parental cell line (PubMed=35381425).
Knockout cell: Method=CRISPR/Cas9; UniProtKB; P21448; Abcb1.
Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_D266 (CHO-CHRC5)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=35381425; DOI=10.1016/j.bbrc.2022.03.148
Limniatis G., Georges E.
Knockout of P-glycoprotein abolish the collateral sensitivity of CHO(R)C5 multidrug resistant cells.
Biochem. Biophys. Res. Commun. 608:23-29(2022)

Cross-references
Encyclopedic resources Wikidata; Q117704243
Entry history
Entry creation21-Mar-2023
Last entry update19-Dec-2024
Version number4