Cellosaurus hIPSC-Di21-C2-4-3 (CVCL_D1FC)
| Cell line name | hIPSC-Di21-C2-4-3 |
|---|---|
| Synonyms | Di C2-4-3; C2-4-3 |
| Accession | CVCL_D1FC |
| Resource Identification Initiative | To cite this cell line use: hIPSC-Di21-C2-4-3 (RRID:CVCL_D1FC) |
| Comments | Population: Caucasian. Characteristics: This cell line has lot one copy of chromosome 21. Using CRISPR/Cas9 a IRES-TK-Neo-polyA site cassette was introduced in one allele of exon 3 of APP on chromosome 21 of the parent cell line. The parent cell line was cultured in the absence of G418 selection for three passages to allow chromosome loss to take place, and then were cultured in the presence of ganciclovir (GCV) to select a clone without the presence of the TK-neo construct (PubMed=23084023). Derived from site: In situ; Chest, skin; UBERON=UBERON_0001868. Cell type: Fibroblast of skin; CL=CL_0002620. |
| Disease | Down syndrome (NCIt: C2993) Down syndrome (ORDO: Orphanet_870) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_D1F9 (hIPSC-Tri21-C2-4) |
| Sex of cell | Female |
| Age at sampling | 1Y |
| Category | Induced pluripotent stem cell |
| Publications | PubMed=23084023; DOI=10.1016/j.stem.2012.08.004; PMCID=PMC3705773 |
| Cross-references | |
| Cell line collections (Providers) | WiCell; hipsc-di21-c2-4-2 |
| Encyclopedic resources | Wikidata; Q127381759 |
| Entry history | |
| Entry creation | 30-Jan-2024 |
| Last entry update | 10-Sep-2024 |
| Version number | 2 |