Cellosaurus cell line CLF_PEDS0005_T2A (CVCL

Cellosaurus CLF_PEDS0005_T2A (CVCL_C9B4)

Cross-references
Cell line name	CLF_PEDS0005_T2A
Synonyms	CLF_PEDS0005_T2a
Accession	CVCL_C9B4
Resource Identification Initiative	To cite this cell line use: CLF_PEDS0005_T2A (RRID:CVCL_C9B4)
Comments	Population: African American. Omics: CRISPR phenotypic screen. Omics: Deep exome analysis. Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations	Gene fusion; HGNC; HGNC:28667; C1orf116 + HGNC; HGNC:11103; SMARCB1; Name(s)=SMARCB1-C1orf116; Note=SMARCB1 intron 1 fused to C1orf116 C-terminal (from autologous cell line CLF_PEDS0005_T1). Gene deletion; HGNC; HGNC:11103; SMARCB1; Zygosity=Heterozygous (from autologous cell line CLF_PEDS0005_T1).
Disease	Kidney medullary carcinoma (NCIt: C7572) Renal medullary carcinoma (ORDO: Orphanet_319319)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C9B2 ! CLF_PEDS0005_N CVCL_C9B3 ! CLF_PEDS0005_T1 CVCL_C9B5 ! CLF_PEDS0005_T2B
Category	Cancer cell line
Publications	PubMed=30860482; DOI=10.7554/eLife.44161; PMCID=PMC6436895 Hong A.L., Tseng Y.-Y., Wala J.A., Kim W.-J., Kynnap B.D., Doshi M.B., Kugener G., Sandoval G.J., Howard T.P., Li J., Yang X.-P., Tillgren M., Ghandi M., Sayeed A., Deasy R., Ward A., McSteen B., Labella K.M., Keskula P., Tracy A., Connor C., Clinton C.M., Church A.J., Crompton B.D., Janeway K.A., Van Hare B., Sandak D., Gjoerup O.V., Bandopadhayay P., Clemons P.A., Schreiber S.L., Root D.E., Gokhale P.C., Chi S.N., Mullen E.A., Roberts C.W.M., Kadoch C., Beroukhim R., Ligon K.L., Boehm J.S., Hahn W.C. Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. eLife 8:e44161.1-e44161.32(2019)
CRISP screens repositories	BioGRID_ORCS_Cell_line; 1223
Encyclopedic resources	Wikidata; Q123030937
Gene expression databases	GEO; GSM3039705
Sequence databases	dbGAP; phs001800.v1.p1
Entry history
Entry creation	05-Oct-2023
Last entry update	19-Dec-2024
Version number	3