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Cellosaurus CLF_PEDS0005_T1 (CVCL_C9B3)

[Text version]
Cell line name CLF_PEDS0005_T1
Accession CVCL_C9B3
Resource Identification Initiative To cite this cell line use: CLF_PEDS0005_T1 (RRID:CVCL_C9B3)
Comments Population: African American.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Gene fusion; HGNC; HGNC:28667; C1orf116 + HGNC; HGNC:11103; SMARCB1; Name(s)=SMARCB1-C1orf116; Note=SMARCB1 intron 1 fused to C1orf116 C-terminal (PubMed=30860482).
  • Gene deletion; HGNC; HGNC:11103; SMARCB1; Zygosity=Heterozygous (PubMed=30860482).
Disease Kidney medullary carcinoma (NCIt: C7572)
Renal medullary carcinoma (ORDO: Orphanet_319319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C9B2 ! CLF_PEDS0005_N
CVCL_C9B4 ! CLF_PEDS0005_T2A
CVCL_C9B5 ! CLF_PEDS0005_T2B
Category Cancer cell line
Publications

PubMed=30860482; DOI=10.7554/eLife.44161; PMCID=PMC6436895
Hong A.L., Tseng Y.-Y., Wala J.A., Kim W.-J., Kynnap B.D., Doshi M.B., Kugener G., Sandoval G.J., Howard T.P., Li J., Yang X.-P., Tillgren M., Ghandi M., Sayeed A., Deasy R., Ward A., McSteen B., Labella K.M., Keskula P., Tracy A., Connor C., Clinton C.M., Church A.J., Crompton B.D., Janeway K.A., Van Hare B., Sandak D., Gjoerup O.V., Bandopadhayay P., Clemons P.A., Schreiber S.L., Root D.E., Gokhale P.C., Chi S.N., Mullen E.A., Roberts C.W.M., Kadoch C., Beroukhim R., Ligon K.L., Boehm J.S., Hahn W.C.
Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.
eLife 8:e44161.1-e44161.32(2019)

Cross-references
Encyclopedic resources Wikidata; Q123030936
Gene expression databases GEO; GSM3039703
Sequence databases dbGAP; phs001800.v1.p1
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3