• Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=21447744; PubMed=29348827).
  

PubMed=12796605; DOI=10.1097/01.COC.0000020960.98562.84
Toretsky J.A., Jenson J., Sun C.-C., Eskenazi A.E., Campbell A., Hunger S.P., Caires A., Frantz C., Hill J.L., Stamberg J.
Translocation (11;15;19): a highly specific chromosome rearrangement associated with poorly differentiated thymic carcinoma in young patients.
Am. J. Clin. Oncol. 26:300-306(2003)

PubMed=17934517; DOI=10.1038/sj.onc.1210852
French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J., Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R., Fletcher J.A., Aster J.C.
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
Oncogene 27:2237-2242(2008)

PubMed=20871596; DOI=10.1038/nature09504; PMCID=PMC3010259
Filippakopoulos P., Qi J., Picaud S., Shen Y., Smith W.B., Fedorov O., Morse E.M., Keates T., Hickman T.T., Felletar I., Philpott M., Munro S., McKeown M.R., Wang Y.-C., Christie A.L., West N.H., Cameron M.J., Schwartz B.E., Heightman T.D., La Thangue N.B., French C.A., Wiest O., Kung A.L.-J., Knapp S., Bradner J.E.
Selective inhibition of BET bromodomains.
Nature 468:1067-1073(2010)

PubMed=21447744; DOI=10.1158/0008-5472.CAN-10-3513; PMCID=PMC3070805
Schwartz B.E., Hofer M.D., Lemieux M.E., Bauer D.E., Cameron M.J., West N.H., Agoston E.S., Reynoird N., Khochbin S., Ince T.A., Christie A.L., Janeway K.A., Vargas S.O., Perez-Atayde A.R., Aster J.C., Sallan S.E., Kung A.L., Bradner J.E., French C.A.
Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Cancer Res. 71:2686-2696(2011)

PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512
Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease.
Oncotarget 8:112313-112329(2017)

PubMed=30135075; DOI=10.1101/gad.315648.118; PMCID=PMC6120715
Liao S., Maertens O., Cichowski K.M., Elledge S.J.
Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.
Genes Dev. 32:1188-1200(2018)