ID   TC-797
AC   CVCL_C8YZ
SY   TC797; NMC 797; NMC797; 797
DR   Wikidata; Q123033608
RX   PubMed=12796605;
RX   PubMed=17934517;
RX   PubMed=20871596;
RX   PubMed=21447744;
RX   PubMed=29348827;
RX   PubMed=30135075;
CC   Sequence variation: Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=21447744; PubMed=29348827).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
//
RX   PubMed=12796605; DOI=10.1097/01.COC.0000020960.98562.84;
RA   Toretsky J.A., Jenson J., Sun C.-C., Eskenazi A.E., Campbell A.,
RA   Hunger S.P., Caires A., Frantz C., Hill J.L., Stamberg J.;
RT   "Translocation (11;15;19): a highly specific chromosome rearrangement
RT   associated with poorly differentiated thymic carcinoma in young
RT   patients.";
RL   Am. J. Clin. Oncol. 26:300-306(2003).
//
RX   PubMed=17934517; DOI=10.1038/sj.onc.1210852;
RA   French C.A., Ramirez C.L., Kolmakova J., Hickman T.T., Cameron M.J.,
RA   Thyne M.E., Kutok J.L., Toretsky J.A., Tadavarthy A.K., Kees U.R.,
RA   Fletcher J.A., Aster J.C.;
RT   "BRD-NUT oncoproteins: a family of closely related nuclear proteins
RT   that block epithelial differentiation and maintain the growth of
RT   carcinoma cells.";
RL   Oncogene 27:2237-2242(2008).
//
RX   PubMed=20871596; DOI=10.1038/nature09504; PMCID=PMC3010259;
RA   Filippakopoulos P., Qi J., Picaud S., Shen Y., Smith W.B., Fedorov O.,
RA   Morse E.M., Keates T., Hickman T.T., Felletar I., Philpott M.,
RA   Munro S., McKeown M.R., Wang Y.-C., Christie A.L., West N.H., Cameron M.J.,
RA   Schwartz B.E., Heightman T.D., La Thangue N.B., French C.A., Wiest O.,
RA   Kung A.L.-J., Knapp S., Bradner J.E.;
RT   "Selective inhibition of BET bromodomains.";
RL   Nature 468:1067-1073(2010).
//
RX   PubMed=21447744; DOI=10.1158/0008-5472.CAN-10-3513; PMCID=PMC3070805;
RA   Schwartz B.E., Hofer M.D., Lemieux M.E., Bauer D.E., Cameron M.J.,
RA   West N.H., Agoston E.S., Reynoird N., Khochbin S., Ince T.A.,
RA   Christie A.L., Janeway K.A., Vargas S.O., Perez-Atayde A.R., Aster J.C.,
RA   Sallan S.E., Kung A.L., Bradner J.E., French C.A.;
RT   "Differentiation of NUT midline carcinoma by epigenomic
RT   reprogramming.";
RL   Cancer Res. 71:2686-2696(2011).
//
RX   PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512;
RA   Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.;
RT   "Molecular-genetic profiling and high-throughput in vitro drug
RT   screening in NUT midline carcinoma-an aggressive and fatal disease.";
RL   Oncotarget 8:112313-112329(2017).
//
RX   PubMed=30135075; DOI=10.1101/gad.315648.118; PMCID=PMC6120715;
RA   Liao S., Maertens O., Cichowski K.M., Elledge S.J.;
RT   "Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma
RT   uncovers a synergism between BETis and CDK4/6is.";
RL   Genes Dev. 32:1188-1200(2018).
//