Cellosaurus cell line PER-704 (CVCL

Cellosaurus PER-704 (CVCL_C8YX)

Cross-references
Cell line name	PER-704
Accession	CVCL_C8YX
Resource Identification Initiative	To cite this cell line use: PER-704 (RRID:CVCL_C8YX)
Comments	Omics: Deep exome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
Sequence variations	Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT; Note=BRD4 exon 15 fused to NUTM1 exon 2 (PubMed=24518598; PubMed=29348827).
Disease	NUT carcinoma (NCIt: C45716) NUT midline carcinoma (ORDO: Orphanet_443167)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	8Y
Category	Cancer cell line
Publications	PubMed=23128391; DOI=10.1038/onc.2012.487 Thompson-Wicking K., Francis R.W., Stirnweiss A., Ferrari E., Welch M.D., Baker E., Murch A.R., Gout A.M., Carter K.W., Charles A.K., Phillips M.B., Kees U.R., Beesley A.H. Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma. Oncogene 32:4664-4674(2013) PubMed=24518598; DOI=10.1038/bjc.2014.54; PMCID=PMC3950881 Beesley A.H., Stirnweiss A., Ferrari E., Endersby R., Howlett M., Failes T.W., Arndt G.M., Charles A.K., Cole C.H., Kees U.R. Comparative drug screening in NUT midline carcinoma. Br. J. Cancer 110:1189-1198(2014) PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512 Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H. Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease. Oncotarget 8:112313-112329(2017)
Encyclopedic resources	Wikidata; Q123033264
Entry history
Entry creation	05-Oct-2023
Last entry update	19-Dec-2024
Version number	3