ID   PER-704
AC   CVCL_C8YX
DR   Wikidata; Q123033264
RX   PubMed=23128391;
RX   PubMed=24518598;
RX   PubMed=29348827;
CC   Sequence variation: Gene fusion; HGNC; HGNC:13575; BRD4 + HGNC; HGNC:29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT; Note=BRD4 exon 15 fused to NUTM1 exon 2 (PubMed=24518598; PubMed=29348827).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Larynx; UBERON=UBERON_0001737.
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
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RX   PubMed=23128391; DOI=10.1038/onc.2012.487;
RA   Thompson-Wicking K., Francis R.W., Stirnweiss A., Ferrari E.,
RA   Welch M.D., Baker E., Murch A.R., Gout A.M., Carter K.W.,
RA   Charles A.K., Phillips M.B., Kees U.R., Beesley A.H.;
RT   "Novel BRD4-NUT fusion isoforms increase the pathogenic complexity in
RT   NUT midline carcinoma.";
RL   Oncogene 32:4664-4674(2013).
//
RX   PubMed=24518598; DOI=10.1038/bjc.2014.54; PMCID=PMC3950881;
RA   Beesley A.H., Stirnweiss A., Ferrari E., Endersby R., Howlett M.,
RA   Failes T.W., Arndt G.M., Charles A.K., Cole C.H., Kees U.R.;
RT   "Comparative drug screening in NUT midline carcinoma.";
RL   Br. J. Cancer 110:1189-1198(2014).
//
RX   PubMed=29348827; DOI=10.18632/oncotarget.22862; PMCID=PMC5762512;
RA   Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.;
RT   "Molecular-genetic profiling and high-throughput in vitro drug
RT   screening in NUT midline carcinoma-an aggressive and fatal disease.";
RL   Oncotarget 8:112313-112329(2017).
//