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Cellosaurus FS1 (CVCL_C8X2)

[Text version]
Cell line name FS1
Accession CVCL_C8X2
Resource Identification Initiative To cite this cell line use: FS1 (RRID:CVCL_C8X2)
Comments Characteristics: Homogenous cell morphology with prominent nucleoli and long cytoplasmic processes. Expresses WT1 and show reversion of the WT1+-KTS isoform ratio. Expresses Sertoli cell markers SOX9, MIC2, AR and INHA. Strongly positive for vimentin, which is expressed in Sertoli cells. Negative for the germ cell marker VASA1 and for the Leydig cell marker LHCGR (Direct_author_submission).
Karyotypic information: 46,XY (PubMed=18271004).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptome analysis by microarray.
Miscellaneous: Detailed characteristics from personal communication of Schulz, Birte.
Derived from site: In situ; Testis; UBERON=UBERON_0000473.
Cell type: Sertoli cell; CL=CL_0000216.
Sequence variations
Disease Frasier syndrome (NCIt: C122805)
Frasier syndrome (ORDO: Orphanet_347)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Transformed cell line
Publications

PubMed=18271004; DOI=10.1002/mrd.20889
Schumacher V., Gueler B., Looijenga L.H.J., Becker J.U., Amann K., Engers R., Dotsch J., Stoop H., Schulz W., Royer-Pokora B.
Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome.
Mol. Reprod. Dev. 75:1484-1494(2008)

PubMed=27688058; DOI=10.1007/s00418-016-1503-y
Hartmann K., Bennien J., Wapelhorst B., Bakhaus K., Schumacher V., Kliesch S., Weidner W., Bergmann M., Geyer J., Fietz D.
Current insights into the sulfatase pathway in human testis and cultured Sertoli cells.
Histochem. Cell Biol. 146:737-748(2016)

PubMed=34153645; DOI=10.1016/j.neo.2021.05.008; PMCID=PMC8233172
Fink C., Baal N., Wilhelm J., Sarode P., Weigel R., Schumacher V., Nettersheim D., Schorle H., Schrock C., Bergmann M., Kliesch S., Kressin M., Savai R.
On the origin of germ cell neoplasia in situ: dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro.
Neoplasia 23:731-742(2021)

PubMed=36899312; DOI=10.1186/s12885-023-10696-7; PMCID=PMC10007848
Schulz B., Schumacher V., Ngezahayo A., Maier-Begandt D., Schadzek N., Wilhelm J., Weidner W., Pilatz A., Fietz D., Kliesch S., Schnepel N., Hambruch N., Rode K., Langeheine M., Brehm R.
Analysis of connexin 43, connexin 45 and N-cadherin in the human Sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies.
BMC Cancer 23:232.1-232.20(2023)

Cross-references
Encyclopedic resources Wikidata; Q123031314
Gene expression databases GEO; GSM5209347
GEO; GSM5209348
GEO; GSM5209349
GEO; GSM5209350
GEO; GSM5209351
GEO; GSM5209352
GEO; GSM5209353
GEO; GSM5209354
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number4