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Cellosaurus CUTO-9 (CVCL_C8TB)

[Text version]
Cell line name CUTO-9
Synonyms CUTO9; Colorado University Thoracic Oncology 9
Accession CVCL_C8TB
Resource Identification Initiative To cite this cell line use: CUTO-9 (RRID:CVCL_C8TB)
Comments Doubling time: 26 +- 0.6 hours (PubMed=35933914).
Omics: Genome sequenced.
Omics: SNP array analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E13A20 v1 fusion (PubMed=35933914).
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=35933914).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=35933914).
  • Mutation; HGNC; HGNC:18040; ARID1B; Simple; p.Pro1838fs*22 (c.5513delC) (p.Pro1851fs*22, c.5552delC); Zygosity=Heterozygous (PubMed=35933914).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gln642Ter (c.1924C>T); ClinVar=VCV000952282; Zygosity=Heterozygous (PubMed=35933914).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
Publications

PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010
Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P., Fransson S., Bergman B., Djos A., Chen N., Martinsson T., Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G.
Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC.
Lung Cancer 171:103-114(2022)

Cross-references
Encyclopedic resources Wikidata; Q123031003
Gene expression databases ArrayExpress; E-MTAB-11342
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3