ID   CUTO-9
AC   CVCL_C8TB
SY   CUTO9; Colorado University Thoracic Oncology 9
DR   ArrayExpress; E-MTAB-11342
DR   Wikidata; Q123031003
RX   PubMed=35933914;
CC   Doubling time: 26 +- 0.6 hours (PubMed=35933914).
CC   Sequence variation: Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E13A20 v1 fusion (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=35933914).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:18040; ARID1B; Simple; p.Pro1838fs*22 (c.5513delC) (p.Pro1851fs*22, c.5552delC); Zygosity=Heterozygous (PubMed=35933914).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gln642Ter (c.1924C>T); ClinVar=VCV000952282; Zygosity=Heterozygous (PubMed=35933914).
CC   Omics: Genome sequenced.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   41Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 19-12-24; Version: 3
//
RX   PubMed=35933914; DOI=10.1016/j.lungcan.2022.07.010;
RA   Bokhari A.A.A., Lai W.-Y., Le A.T., Gabre J.L., Chuang T.-P.,
RA   Fransson S., Bergman B., Djos A., Chen N., Martinsson T.,
RA   Van den Eynden J., Doebele R.C., Palmer R.H., Hallberg B., Umapathy G.;
RT   "Novel human-derived EML4-ALK fusion cell lines identify
RT   ribonucleotide reductase RRM2 as a target of activated ALK in
RT   NSCLC.";
RL   Lung Cancer 171:103-114(2022).
//