Cell line name |
MCF-7 AC1 |
Synonyms |
AC-1; Ac-1; AC1; Ac1 |
Accession |
CVCL_C8MT |
Resource Identification Initiative |
To cite this cell line use: MCF-7 AC1 (RRID:CVCL_C8MT) |
Comments |
Population: Caucasian. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2594; CYP19A1. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) Children:
|
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=16885381; DOI=10.1158/0008-5472.CAN-05-3984 Macedo L.F., Guo Z.-Y., Tilghman S.L., Sabnis G.J., Qiu Y., Brodie A.M.H. Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res. 66:7775-7782(2006) PubMed=17942301; DOI=10.1016/j.jsbmb.2007.04.005; PMCID=PMC3081608 Sabnis G.J., Macedo L.F., Goloubeva O., Schayowitz A.B., Zhu Y., Brodie A.M.H. Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model. J. Steroid Biochem. Mol. Biol. 108:1-7(2008) PubMed=22659283; DOI=10.1016/j.jsbmb.2012.05.008; PMCID=PMC3463743 Schech A.J., Nemieboka B.E., Brodie A.M.H. Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction. J. Steroid Biochem. Mol. Biol. 132:195-202(2012) PubMed=24472707; DOI=10.1186/bcr3609; PMCID=PMC3978891 Kazi A.A., Gilani R.A., Schech A.J., Chumsri S., Sabnis G.J., Shah P., Goloubeva O., Kronsberg S.S., Brodie A.M.H. Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer. Breast Cancer Res. 16:R15.1-R15.18(2014) |
Cross-references |
Encyclopedic resources |
Wikidata; Q123033005
|
Entry history |
Entry creation | 05-Oct-2023 |
Last entry update | 19-Dec-2024 |
Version number | 4 |
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