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Cellosaurus MCF-7 AC1 (CVCL_C8MT)

[Text version]
Cell line name MCF-7 AC1
Synonyms AC-1; Ac-1; AC1; Ac1
Accession CVCL_C8MT
Resource Identification Initiative To cite this cell line use: MCF-7 AC1 (RRID:CVCL_C8MT)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2594; CYP19A1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Children:
CVCL_C8NC (MCF-7 AC1-ExR)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=16885381; DOI=10.1158/0008-5472.CAN-05-3984
Macedo L.F., Guo Z.-Y., Tilghman S.L., Sabnis G.J., Qiu Y., Brodie A.M.H.
Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole.
Cancer Res. 66:7775-7782(2006)

PubMed=17942301; DOI=10.1016/j.jsbmb.2007.04.005; PMCID=PMC3081608
Sabnis G.J., Macedo L.F., Goloubeva O., Schayowitz A.B., Zhu Y., Brodie A.M.H.
Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model.
J. Steroid Biochem. Mol. Biol. 108:1-7(2008)

PubMed=22659283; DOI=10.1016/j.jsbmb.2012.05.008; PMCID=PMC3463743
Schech A.J., Nemieboka B.E., Brodie A.M.H.
Zoledronic acid inhibits aromatase activity and phosphorylation: potential mechanism for additive zoledronic acid and letrozole drug interaction.
J. Steroid Biochem. Mol. Biol. 132:195-202(2012)

PubMed=24472707; DOI=10.1186/bcr3609; PMCID=PMC3978891
Kazi A.A., Gilani R.A., Schech A.J., Chumsri S., Sabnis G.J., Shah P., Goloubeva O., Kronsberg S.S., Brodie A.M.H.
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer.
Breast Cancer Res. 16:R15.1-R15.18(2014)

Cross-references
Encyclopedic resources Wikidata; Q123033005
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number4