ID   MCF-7 AC1
AC   CVCL_C8MT
SY   AC-1; Ac-1; AC1; Ac1
DR   Wikidata; Q123033005
RX   PubMed=16885381;
RX   PubMed=17942301;
RX   PubMed=22659283;
RX   PubMed=24472707;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2594; CYP19A1.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-09-24; Version: 3
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RX   PubMed=16885381; DOI=10.1158/0008-5472.CAN-05-3984;
RA   Macedo L.F., Guo Z.-Y., Tilghman S.L., Sabnis G.J., Qiu Y.,
RA   Brodie A.M.H.;
RT   "Role of androgens on MCF-7 breast cancer cell growth and on the
RT   inhibitory effect of letrozole.";
RL   Cancer Res. 66:7775-7782(2006).
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RX   PubMed=17942301; DOI=10.1016/j.jsbmb.2007.04.005; PMCID=PMC3081608;
RA   Sabnis G.J., Macedo L.F., Goloubeva O., Schayowitz A.B., Zhu Y.,
RA   Brodie A.M.H.;
RT   "Toremifene-atamestane; alone or in combination: predictions from the
RT   preclinical intratumoral aromatase model.";
RL   J. Steroid Biochem. Mol. Biol. 108:1-7(2008).
//
RX   PubMed=22659283; DOI=10.1016/j.jsbmb.2012.05.008; PMCID=PMC3463743;
RA   Schech A.J., Nemieboka B.E., Brodie A.M.H.;
RT   "Zoledronic acid inhibits aromatase activity and phosphorylation:
RT   potential mechanism for additive zoledronic acid and letrozole drug
RT   interaction.";
RL   J. Steroid Biochem. Mol. Biol. 132:195-202(2012).
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RX   PubMed=24472707; DOI=10.1186/bcr3609; PMCID=PMC3978891;
RA   Kazi A.A., Gilani R.A., Schech A.J., Chumsri S., Sabnis G.J., Shah P.,
RA   Goloubeva O., Kronsberg S.S., Brodie A.M.H.;
RT   "Nonhypoxic regulation and role of hypoxia-inducible factor 1 in
RT   aromatase inhibitor resistant breast cancer.";
RL   Breast Cancer Res. 16:R15.1-R15.18(2014).
//