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Cellosaurus HL-60-79B (CVCL_C8HN)

[Text version]
Cell line name HL-60-79B
Synonyms HL-60(8q+)
Accession CVCL_C8HN
Resource Identification Initiative To cite this cell line use: HL-60-79B (RRID:CVCL_C8HN)
Comments Population: Caucasian.
Karyotypic information: Has an abnormally banded region on chromosome 8 (PubMed=3475162; PubMed=6580529).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=6580529; DOI=10.1038/306494a0
Nowell P.C., Finan J., Dalla-Favera R., Gallo R.C., ar-Rushdi A., Romanczuk H., Selden J.R., Emanuel B.S., Rovera G., Croce C.M.
Association of amplified oncogene c-myc with an abnormally banded chromosome 8 in a human leukaemia cell line.
Nature 306:494-497(1983)

PubMed=3475162; DOI=10.1016/0165-4608(87)90362-1
Misawa S.-i., Staal S.P., Testa J.R.
Amplification of the c-myc oncogene is associated with an abnormally banded region on chromosome 8 or double minute chromosomes in two HL-60 human leukemia sublines.
Cancer Genet. Cytogenet. 28:127-135(1987)

Cross-references
Encyclopedic resources Wikidata; Q123031677
Entry history
Entry creation05-Oct-2023
Last entry update19-Dec-2024
Version number3