ID   HL-60-79B
AC   CVCL_C8HN
SY   HL-60(8q+)
DR   Wikidata; Q123031677
RX   PubMed=3475162;
RX   PubMed=6580529;
CC   Population: Caucasian.
CC   Karyotypic information: Has an abnormally banded region on chromosome 8 (PubMed=3475162; PubMed=6580529).
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 30-01-24; Version: 2
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RX   PubMed=3475162; DOI=10.1016/0165-4608(87)90362-1;
RA   Misawa S.-i., Staal S.P., Testa J.R.;
RT   "Amplification of the c-myc oncogene is associated with an abnormally
RT   banded region on chromosome 8 or double minute chromosomes in two
RT   HL-60 human leukemia sublines.";
RL   Cancer Genet. Cytogenet. 28:127-135(1987).
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RX   PubMed=6580529; DOI=10.1038/306494a0;
RA   Nowell P.C., Finan J., Dalla-Favera R., Gallo R.C., ar-Rushdi A.,
RA   Romanczuk H., Selden J.R., Emanuel B.S., Rovera G., Croce C.M.;
RT   "Association of amplified oncogene c-myc with an abnormally banded
RT   chromosome 8 in a human leukaemia cell line.";
RL   Nature 306:494-497(1983).
//