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Cellosaurus SK-N-MM (CVCL_C8G1)

[Text version]
Cell line name SK-N-MM
Synonyms SKNMM
Accession CVCL_C8G1
Resource Identification Initiative To cite this cell line use: SK-N-MM (RRID:CVCL_C8G1)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 886; ATRX; Unexplicit; Ex1-11del; Zygosity=Heterozygous (PubMed=31631027).
  • Mutation; HGNC; 886; ATRX; Simple; p.Lys1367Ter (c.4099A>T); Zygosity=Heterozygous (PubMed=31631027; DepMap=ACH-002922).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Homozygous (DepMap=ACH-002922).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=9815755
Cheung I.Y., Cheung N.-K.V.
Molecular detection of GAGE expression in peripheral blood and bone marrow: utility as a tumor marker for neuroblastoma.
Clin. Cancer Res. 3:821-826(1997)

PubMed=31631027; DOI=10.1016/j.ccell.2019.09.002
Qadeer Z.A., Valle-Garcia D., Hasson D., Sun Z., Cook A., Nguyen C., Soriano A., Ma A.-Q., Griffiths L.M., Zeineldin M., Filipescu D., Jubierre L., Chowdhury A., Deevy O., Chen X., Finkelstein D.B., Bahrami A., Stewart E., Federico S.M., Gallego S., Dekio F., Fowkes M.E., Meni D., Maris J.M., Weiss W.A., Roberts S.S., Cheung N.-K.V., Jin J., Segura M.F., Dyer M.A., Bernstein E.
ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition via modulation of neuronal gene signatures.
Cancer Cell 36:512-527.e9(2019)

Cross-references
Cell line databases/resources DepMap; ACH-002922
Encyclopedic resources Wikidata; Q123033507
Entry history
Entry creation29-Jun-2023
Last entry update02-May-2024
Version number3