ID   SK-N-MM
AC   CVCL_C8G1
SY   SKNMM
DR   DepMap; ACH-002922
DR   Wikidata; Q123033507
RX   PubMed=9815755;
RX   PubMed=31631027;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Sequence variation: Mutation; HGNC; 886; ATRX; Unexplicit; Ex1-11del; Zygosity=Heterozygous (PubMed=31631027).
CC   Sequence variation: Mutation; HGNC; 886; ATRX; Simple; p.Lys1367Ter (c.4099A>T); Zygosity=Heterozygous (PubMed=31631027; DepMap=ACH-002922).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Homozygous (DepMap=ACH-002922).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   8Y
CA   Cancer cell line
DT   Created: 29-06-23; Last updated: 02-05-24; Version: 3
//
RX   PubMed=9815755;
RA   Cheung I.Y., Cheung N.-K.V.;
RT   "Molecular detection of GAGE expression in peripheral blood and bone
RT   marrow: utility as a tumor marker for neuroblastoma.";
RL   Clin. Cancer Res. 3:821-826(1997).
//
RX   PubMed=31631027; DOI=10.1016/j.ccell.2019.09.002; PMCID=PMC6851493;
RA   Qadeer Z.A., Valle-Garcia D., Hasson D., Sun Z., Cook A., Nguyen C.,
RA   Soriano A., Ma A.-Q., Griffiths L.M., Zeineldin M., Filipescu D.,
RA   Jubierre L., Chowdhury A., Deevy O., Chen X., Finkelstein D.B.,
RA   Bahrami A., Stewart E., Federico S.M., Gallego S., Dekio F., Fowkes M.E.,
RA   Meni D., Maris J.M., Weiss W.A., Roberts S.S., Cheung N.-K.V., Jin J.,
RA   Segura M.F., Dyer M.A., Bernstein E.;
RT   "ATRX in-frame fusion neuroblastoma is sensitive to EZH2 inhibition
RT   via modulation of neuronal gene signatures.";
RL   Cancer Cell 36:512-527.e9(2019).
//