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Cellosaurus OS052 (CVCL_C8FR)

[Text version]
Cell line name OS052
Synonyms PSS008
Accession CVCL_C8FR
Resource Identification Initiative To cite this cell line use: OS052 (RRID:CVCL_C8FR)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
Characteristics: Metastatic (PubMed=37703185).
Omics: Genome sequenced.
Omics: Transcriptome analysis by RNAseq.
Miscellaneous: Equivalence of OS052 with PSS008 from personal communication of Sayles, Leanne C.
Derived from site: In situ; Bone, fibula; UBERON=UBERON_0001446.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu465Lysfs*13 (c.1392delA) (c.1391delA); ClinVar=VCV000954138; Zygosity=Homozygous (DepMap=ACH-002471).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 17Y
Category Cancer cell line
STR profile Source(s): PubMed=37703185

Markers:
AmelogeninX
CSF1PO11,12
D5S81811
D7S8209,11
D13S31713
D16S53911
TH019.3
TPOX8
vWA17,18

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Publications

PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121
Schott C.R., Koehne A.L., Sayles L.C., Young E.P., Luck C., Yu K., Lee A.G., Breese M.R., Leung S.G., Xu H., Shah A.T., Liu H.-Y., Spillinger A., Behroozfard I.H., Marini K.D., Dinh P.T., Pons-Ventura M.V., Vanderboon E.N., Hazard F.K., Cho S.-J., Avedian R.S., Mohler D.G., Zimel M., Wustrack R., Curtis C., Sirota M., Sweet-Cordero E.A.
Osteosarcoma PDX-derived cell line models for preclinical drug evaluation demonstrate metastasis inhibition by dinaciclib through a genome-targeted approach.
Clin. Cancer Res. 30:849-864(2024)

Cross-references
Cell line databases/resources DepMap; ACH-002471
Encyclopedic resources Wikidata; Q123033220
Entry history
Entry creation29-Jun-2023
Last entry update19-Dec-2024
Version number6