ID   OS052
AC   CVCL_C8FR
SY   PSS008
DR   DepMap; ACH-002471
DR   Wikidata; Q123033220
RX   PubMed=37703185;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Characteristics: Established from a patient-derived xenograft established by implantation of the original tumor under the renal capsule of NSG mice (PubMed=37703185).
CC   Characteristics: Metastatic (PubMed=37703185).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Glu465Lysfs*13 (c.1392delA) (c.1391delA); ClinVar=VCV000954138; Zygosity=Homozygous (DepMap=ACH-002471).
CC   Omics: Genome sequenced.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Miscellaneous: Equivalence of OS052 with PSS008 from personal communication of Sayles, Leanne C.
CC   Derived from site: In situ; Bone, fibula; UBERON=UBERON_0001446.
ST   Source(s): PubMed=37703185
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 13
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 9,11
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   17Y
CA   Cancer cell line
DT   Created: 29-06-23; Last updated: 19-12-24; Version: 6
//
RX   PubMed=37703185; DOI=10.1158/1078-0432.CCR-23-0873; PMCID=PMC10870121;
RA   Schott C.R., Koehne A.L., Sayles L.C., Young E.P., Luck C., Yu K.,
RA   Lee A.G., Breese M.R., Leung S.G., Xu H., Shah A.T., Liu H.-Y.,
RA   Spillinger A., Behroozfard I.H., Marini K.D., Dinh P.T.,
RA   Pons-Ventura M.V., Vanderboon E.N., Hazard F.K., Cho S.-J.,
RA   Avedian R.S., Mohler D.G., Zimel M., Wustrack R., Curtis C.,
RA   Sirota M., Sweet-Cordero E.A.;
RT   "Osteosarcoma PDX-derived cell line models for preclinical drug
RT   evaluation demonstrate metastasis inhibition by dinaciclib through a
RT   genome-targeted approach.";
RL   Clin. Cancer Res. 30:849-864(2024).
//