Cellosaurus cell line Ma-Mel-86f (CVCL

Cellosaurus Ma-Mel-86f (CVCL_C7TQ)

Cross-references
Cell line name	Ma-Mel-86f
Accession	CVCL_C7TQ
Resource Identification Initiative	To cite this cell line use: Ma-Mel-86f (RRID:CVCL_C7TQ)
Comments	Characteristics: Has lost HLA class I surface expression due to the deletion of B2M (PubMed=27261508). Omics: SNP array analysis. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Homozygous (PubMed=27261508). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24His (c.71G>A); ClinVar=VCV000016929; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro193Ser (c.577C>T); dbSNP=rs1595884713; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs (c.633_645delAGATCCTCAGTTT); Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.741_742delinsTT) (c.741_742CC>TT); ClinVar=VCV000437017; Zygosity=Unspecified (PubMed=27261508).
Disease	Cutaneous nodular melanoma (NCIt: C4225)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A221 ! Ma-Mel-86a CVCL_A222 ! Ma-Mel-86b CVCL_C7TP ! Ma-Mel-86c
Sex of cell	Female
Age at sampling	40Y
Category	Cancer cell line
Publications	PubMed=27261508; DOI=10.1158/0008-5472.CAN-16-0008 Zhao F., Sucker A., Horn S., Heeke C., Bielefeld N., Schrors B., Bicker A., Lindemann M., Roesch A., Gaudernack G., Stiller M., Becker J.C., Lennerz V., Wolfel T., Schadendorf D., Griewank K.G., Paschen A. Melanoma lesions independently acquire T-cell resistance during metastatic latency. Cancer Res. 76:4347-4358(2016)
Encyclopedic resources	Wikidata; Q117704639
Gene expression databases	GEO; GSM2135606
Polymorphism and mutation databases	Progenetix; CVCL_C7TQ
Entry history
Entry creation	21-Mar-2023
Last entry update	19-Dec-2024
Version number	5