Cellosaurus cell line Ma-Mel-86b (CVCL

Cellosaurus Ma-Mel-86b (CVCL_A222)

Cross-references
Cell line name	Ma-Mel-86b
Synonyms	Ma-Mel_86b; Ma-Mel 86b
Accession	CVCL_A222
Resource Identification Initiative	To cite this cell line use: Ma-Mel-86b (RRID:CVCL_A222)
Comments	Characteristics: Has lost HLA class I surface expression due to the deletion of B2M (PubMed=27261508). Omics: SNP array analysis. Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations	Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Homozygous (PubMed=27261508). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=16827748; PubMed=27261508). Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24His (c.71G>A); ClinVar=VCV000016929; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro193Ser (c.577C>T); dbSNP=rs1595884713; Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs (c.633_645delAGATCCTCAGTTT); Zygosity=Unspecified (PubMed=27261508). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.741_742delinsTT) (c.741_742CC>TT); ClinVar=VCV000437017; Zygosity=Unspecified (PubMed=27261508).
Disease	Cutaneous nodular melanoma (NCIt: C4225)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_A221 ! Ma-Mel-86a CVCL_C7TP ! Ma-Mel-86c CVCL_C7TQ ! Ma-Mel-86f
Sex of cell	Female
Age at sampling	35Y
Category	Cancer cell line
Publications	PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R. Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res. 19:290-302(2006) PubMed=27261508; DOI=10.1158/0008-5472.CAN-16-0008 Zhao F., Sucker A., Horn S., Heeke C., Bielefeld N., Schrors B., Bicker A., Lindemann M., Roesch A., Gaudernack G., Stiller M., Becker J.C., Lennerz V., Wolfel T., Schadendorf D., Griewank K.G., Paschen A. Melanoma lesions independently acquire T-cell resistance during metastatic latency. Cancer Res. 76:4347-4358(2016)
Cell line databases/resources	cancercelllines; CVCL_A222
Encyclopedic resources	Wikidata; Q54903861
Gene expression databases	GEO; GSM109093 GEO; GSM2135604
Polymorphism and mutation databases	Progenetix; CVCL_A222
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	14