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Cellosaurus A673-SLFN11-KO (CVCL_C6N5)

[Text version]
Cell line name A673-SLFN11-KO
Accession CVCL_C6N5
Resource Identification Initiative To cite this cell line use: A673-SLFN11-KO (RRID:CVCL_C6N5)
Comments Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 26633; SLFN11.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0080 (A-673)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line

PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089
Gartrell J., Mellado-Largarde M., Clay M.R., Bahrami A., Sahr N.A., Sykes A., Blankenship K., Hoffmann L., Xie J., Cho H.P., Twarog N., Connelly M., Yan K.-K., Yu J.-Y., Porter S.N., Pruett-Miller S.M., Neale G., Tinkle C.L., Federico S.M., Stewart E.A., Shelat A.A.
SLFN11 is widely expressed in pediatric sarcoma and induces variable sensitization to replicative stress caused by DNA-damaging agents.
Mol. Cancer Ther. 20:2151-2165(2021)

Encyclopedic resources Wikidata; Q116048466
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3