ID   A673-SLFN11-KO
AC   CVCL_C6N5
DR   Wikidata; Q116048466
RX   PubMed=34413129;
CC   Problematic cell line: Misclassified. Parent cell line (A-673) was originally thought to be a rhabdomyosarcoma cell line but is an Ewing sarcoma cell line.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:26633; SLFN11.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala119Glnfs*5 (c.353_354dupCA) (c.354_355insCA); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Muscle; UBERON=UBERON_0001630.
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0080 ! A-673
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 5
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RX   PubMed=34413129; DOI=10.1158/1535-7163.MCT-21-0089; PMCID=PMC8571037;
RA   Gartrell, Jessica
RA   Mellado-Largarde, Marcia
RA   Clay, Michael R.
RA   Bahrami, Armita
RA   Sahr, Natasha A.
RA   Sykes, April D.
RA   Blankenship, Kaley
RA   Hoffmann, Lauren
RA   Xie, Jia
RA   Cho, Hyekyung P.
RA   Twarog, Nathaniel
RA   Connelly, Michele
RA   Yan, Koon-Kiu
RA   Yu, Ji-Yang
RA   Porter, Shaina N.
RA   Pruett-Miller, Shondra M.
RA   Neale, Geoffrey
RA   Tinkle, Christopher L.
RA   Federico, Sara M.
RA   Stewart, Elizabeth A.
RA   Shelat, Anang A.
RT   "SLFN11 is widely expressed in pediatric sarcoma and induces variable
RT   sensitization to replicative stress caused by DNA-damaging agents.";
RL   Mol. Cancer Ther. 20:2151-2165(2021).
//