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Cellosaurus MCF-7/PTX (CVCL_C5RS)

[Text version]
Cell line name MCF-7/PTX
Synonyms MCF7/PTX; MCF-7/P
Accession CVCL_C5RS
Resource Identification Initiative To cite this cell line use: MCF-7/PTX (RRID:CVCL_C5RS)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=24292090; DOI=10.1039/c3mb70428a
Chen S.-Y., Dong Q., Hu S.-S., Cai J.-X., Zhang W.-P., Sun J.-Y., Wang T.-T., Xie J., He H.-R., Xing J.-F., Lu J., Dong Y.-L.
Proteomic analysis of the proteins that are associated with the resistance to paclitaxel in human breast cancer cells.
Mol. Biosyst. 10:294-303(2014)

PubMed=25760096; DOI=10.3892/mmr.2015.3468
Zhang W.-P., Cai J.-X., Chen S.-Y., Zheng X.-W., Hu S.-S., Dong W.-H., Lu J., Xing J.-F., Dong Y.-L.
Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway.
Mol. Med. Rep. 12:1506-1514(2015)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL4483128
ChEMBL-Targets; CHEMBL4483255
Encyclopedic resources Wikidata; Q116049773
Entry history
Entry creation15-Dec-2022
Last entry update29-Jun-2023
Version number3