ID   MCF-7/PTX
AC   CVCL_C5RS
SY   MCF7/PTX; MCF-7/P
DR   ChEMBL-Cells; CHEMBL4483128
DR   ChEMBL-Targets; CHEMBL4483255
DR   Wikidata; Q116049773
RX   PubMed=24292090;
RX   PubMed=25760096;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
//
RX   PubMed=24292090; DOI=10.1039/c3mb70428a;
RA   Chen S.-Y., Dong Q., Hu S.-S., Cai J.-X., Zhang W.-P., Sun J.-Y.,
RA   Wang T.-T., Xie J., He H.-R., Xing J.-F., Lu J., Dong Y.-L.;
RT   "Proteomic analysis of the proteins that are associated with the
RT   resistance to paclitaxel in human breast cancer cells.";
RL   Mol. Biosyst. 10:294-303(2014).
//
RX   PubMed=25760096; DOI=10.3892/mmr.2015.3468;
RA   Zhang W.-P., Cai J.-X., Chen S.-Y., Zheng X.-W., Hu S.-S.,
RA   Dong W.-H., Lu J., Xing J.-F., Dong Y.-L.;
RT   "Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol
RT   through suppression of the SET/phosphatidylinositol 3-kinase/Akt
RT   pathway.";
RL   Mol. Med. Rep. 12:1506-1514(2015).
//